Principal Scientist, Cell Line Engineering

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

The Mammalian Expression Technologies Center of Excellence (MET CoE) at GSK Vaccines is responsible for the generation of CHO-based production cell lines for the expression of innovative recombinant protein vaccines.

The MET CoE is looking for a motivated scientist to support next-generation cell line engineering initiatives. Located in Cambridge, MA, the position will play a significant role in shaping current and next generation GSK’s leading vaccine platforms to accelerate addressing unmet medical needs. This role provides the opportunity to integrate a diverse group of top talented experts in the vaccines industry, lead key activities and further grow and progress in your career. These activities will include:

• Design and develop omics-based screening strategies for discovery of novel gene targets in CHO cells.
• Perform advanced NGS data analytics to elucidate key biological targets for next-generation CHO host evolution.
• Stay up to date with the latest quality and regulatory guidance to support project documentation and accelerated CMC timelines.

The successful applicant may spend 3-6 months within the first year of hire in Rockville, MD to support and guarantee a smooth transition of methods and know-how to the new laboratories in Cambridge, MA.

Basic Qualifications:

• PhD with 2+ years’ industry experience in molecular biology, computational biology, genetics, or another relevant field.
• Two or more years of experience with NGS techniques (wet and dry lab) and associated methodologies, including analyses of large datasets.
• Two or more years of experience with the implementation of genome-scale modelling approaches to establish biological and mechanistic networks.

Preferred Qualifications:

• Hands-on experience with mammalian cell culture, including clonal derivation and transfection.
• Experience with genome-editing tools for mammalian cell engineering.
• Deep understanding in CMC drug substance space as it relates to cell line development.

Why GSK?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns. Our success absolutely depends on our people. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.