Sr. Scientist, Antibody Engineer – Molecular Design & Development

About the Company:

Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.

Function:

Molecular Design & Development

Level:

Sr. Scientist I/II

Location:

Foster City, CA

Reporting Manager:

Director, Molecular Design & Development

About the Opportunity:

The Molecular Design & Development department at Dren Bio is seeking to recruit a scientist to join our bispecific antibody engineering effort. This scientist will work within a team responsible for antibody discovery, engineering and expression for therapeutic molecules and research proteins and with many technologies including phage display. This role will be responsible for generating, maturing and engineering new antibodies to support development of therapeutic molecules as well as critical reagent molecules.

Role and Responsibilities:

We are seeking an individual who can found a display discovery laboratory and implement a new workflow for this technology in Dren’s discovery pipeline.

In the day-to-day, this role will emphasize in-house discovery and engineering of new antibodies, specifically:

1. Generation of new binding clones for both therapeutic and reagent antibodies by display technologies
2. Selection cascade by functional and biophysical characterization testing
3. Secondary library generation, maturation and de-immunization of therapeutic candidates
4. Design and analysis of bispecific and multi-specific antibodies based on target candidate profile

Education, Experience and Qualification Requirements:

Ph.D or equivalent in Biochemistry, Protein Engineering, or a related field

5-10 years’ experience in the biopharmaceutical industry, field or a related protein-science

Experience with phage display or yeast display technology is required

Core Competencies, Knowledge and Skill Requirements:

Apply extensive knowledge in molecular biology techniques, antibody engineering methods and discovery campaign best practices.

Work hands-on to develop our discovery capabilities; experience in antibody or protein characterization is essential.

Excellent problem-solving capabilities and organized work habits, including data management and record keeping.

Ability to collaborate across teams, with clarity in written and verbal communication skills.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $144,000 and $184,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio's Human Resources department can share more about the specific pay range based on the market location of the candidate.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to