Summary of Position:
The Associate Engineer will work as part of a team, under the direction of the group leader/manager, to conduct laboratory experiments to support the development of robust scalable LNP-encapsulated nucleic acids formulations and manufacturing processes, including lab-scale process development, process scaleup, and in-process characterization. The ideal candidate will be proactive, enthusiastic, and show a passion for LNP-RNA formulation and process development. The applicant should have strong communication and collaboration skills, along with a background in LNP formulation and process development.
Specific Responsibilities:
- Executes studies to define formulation components, vehicle, and primary container.
- Operates common biopharmaceutical unit operations such as mixing, dialysis, tangential flow filtration, and sterile filtration.
- Support efforts in fill/finish process optimization, process characterization, technology transfer, and regulatory documentation for our LNP formulations candidates.
- Interface with External Manufacturing, Quality and Regulatory organizations to execute on strategies for GLP or GMP batches.
- Performs in-process characterization such as pH, particle size, encapsulation efficiency measurement, etc.
- Manage daily pre-formulation/material assessments of LNP screening and development.
- Support troubleshooting and technical investigations as needed.
- Responsible for executing or supporting experiments to meet agreed upon deliverables and timelines.
- Optimize existing formulation methods and processes and generate standard operating procedures (SOPs) and test method documents.
- Maintain thorough and detailed electronic lab notebooks and documentation records.
- Support and participate in R&D and project management meetings. Prepare PowerPoint slides and present your findings to multi-disciplinary teams.
- Adhere to all laboratory safety requirements and procedures.
- Assist in maintaining general laboratory functionality and lab equipment.
- Assist in ordering and receiving of lab supplies.
- Exercise judgment within defined procedures and practices to determine appropriate action.
Qualifications:
- B.S. or M.S. in chemical engineering, bioengineering, pharmaceutical sciences.
- Foundation in chemistry, materials science, bio-engineering, chemical engineering, or related field.
- Strong written and oral communication skills, comfort with a "start-up environment."
- Familiarity using CAD software such as Solidworks or AutoCAD is an advantage.
Salary Range: *$115,000 - $135,000
*Please note that for remote positions, salary may be adjusted for cost of living.
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