Pre-Clinical Research: Engineering CD34+ Hematopoietic Stem Cells

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Pre-Clinical Research: Engineering CD34+ Hematopoietic Stem Cells

Location: 3739 Balboa Street #1057, San Francisco, CA 94121, United States

Job Posted Date: July 23, 2024

Positions Available: Part-time, Postdoc, Volunteer

Population: Life Sciences

Our organization received funding and is conducting pre-clinical research in transplant medicine, focusing on genetic engineering techniques to improve organ transplant compatibility and reduce rejection. The intention of the pre-clinical trial is to get the results published in a scientific journal and evaluate implementation in transplant recipients.

We are specifically studying two potential pathways:

1. Deactivation of HLA genes in donor organs using CRISPR-Cas9 delivered via lentiviral vectors or electroporation.
2. Creating chimeric bone marrow via engineered CD34+ cells.

Job Requirements:

Experience/Skills:

1. Gene knockout engineering using lentiviral vectors or electroporation and CRISPR-Cas9
2. Strong knowledge of the immune system
3. Good Laboratory Practice (GLP) standards with animal models
4. Research design and scientific investigation background

Preferred Experience:

1. Understanding of hematopoietic stem cell chimerism
2. Familiarity with FDA approval processes
3. Post-doctorate or PhD

How to Apply:

Send email with resume to