Principal Scientist/Associate Director, Protein Engineering

Open positions

Location: Boston, MA

Job Id: R096-R2

# of Openings: 1

We seek an energetic and motivated Principal Scientist or Associate Director to lead the design and execution of strategies to engineer hematopoietic stem cells by a combination of genetic and protein engineering approaches.

You will join a team of scientists dedicated to moving a novel gene therapy drug candidate into the clinic. Join us and be part of building a company revolutionizing the reach and access of the curative power of genomic medicines for patients with serious diseases.

Responsibilities:

• Lead the design and testing of fusion proteins and antibodies in different formats to optimize their function.
• Lead therapeutic antibody selection, design, and optimization for antibody discovery programs.
• Oversee the development of assays to screen and test the function and affinity of antibodies and recombinant proteins.
• Manage CROs in development and characterization of therapeutic antibodies, developing and guiding the research plan and ensuring timely delivery of data.

Qualifications:

Required:

• A Doctoral Degree in biochemistry, molecular biology or related field with a minimum of eight years of experience in the biotechnology/pharmaceutical industry and/or an academic setting (industry experience is preferred).
• Demonstrated expertise applying molecular biology and protein engineering approaches to optimize the function of antibodies and other proteins.
• Proficiency in molecular biology techniques.
• Experience expressing proteins in mammalian cells.
• Experience developing and implementing functional and affinity assays to characterize antibodies.
• Hands-on experience using display approaches to select and screen novel therapeutic antibodies.